From the Research
Achlorhydria is a condition characterized by the destruction of gastric parietal cells, resulting in hypochlorhydria and eventual achlorhydria, as seen in autoimmune gastritis (AIG) 1. This condition is marked by the permanent loss of gastric acid, which has significant impacts on the body, including hypergastrinemia and increased N-nitroso compounds, both of which increase the risk of gastric cancers. Some key points to consider about achlorhydria include:
- The destruction of oxyntic glands in the corpus, leading to atrophy and loss of gastric acid production 1
- The potential for hypergastrinemia and increased N-nitroso compounds, which increase the risk of gastric cancers 1
- The importance of addressing the underlying cause of achlorhydria, such as autoimmune disorders or long-term use of proton pump inhibitors or H2 blockers
- The potential for supplementation with hydrochloric acid (betaine HCl) with meals, digestive enzymes, and nutrients that may become deficient, such as vitamin B12, iron, and calcium
- The need for proper medical evaluation and management to prevent serious complications like malnutrition, osteoporosis, or increased risk of certain infections It is also worth noting that achlorhydria can be a cause of iron deficiency anemia, as seen in studies where achlorhydric patients had severe malabsorption of nonheme iron, which persisted after the development of iron deficiency 2. Treatment should focus on addressing the underlying cause and may include supplementation with hydrochloric acid (betaine HCl) with meals, digestive enzymes, and nutrients that may become deficient, such as vitamin B12, iron, and calcium 1.