From the Research
Brixadi (buprenorphine) administration and ordering should be guided by the most recent and highest quality study, which is not directly provided in the given evidence, but based on the available information, the medication comes in two formulations: weekly and monthly doses. To administer and order Brixadi, healthcare providers must consider the patient's individual needs and medical history.
- The medication is used for treating opioid use disorder.
- Before initiating treatment, patients should be in mild-to-moderate withdrawal and have previously taken a test dose of transmucosal buprenorphine.
- Administration involves preparing the injection site with an alcohol swab, then injecting the full contents of the pre-filled syringe subcutaneously at a 45-degree angle.
- Rotate injection sites with each dose.
- When ordering, specify the formulation strength and frequency needed.
- Weekly doses are typically used for induction and early stabilization, while monthly doses are for maintenance after stabilization.
- Store Brixadi refrigerated at 2-8°C (36-46°F) and allow it to reach room temperature for 15 minutes before administration.
- The medication works by partially activating opioid receptors, reducing cravings and withdrawal symptoms while blocking the effects of other opioids, making it effective for long-term opioid use disorder management, as seen in studies such as 1. However, the provided evidence does not directly discuss Brixadi, but rather focuses on antipsychotic medications such as paliperidone and aripiprazole, as seen in studies such as 2, 3, 4, and 5. Given the lack of direct evidence on Brixadi, the administration and ordering guidelines should be based on the most recent and highest quality study available, which may not be included in the provided evidence. In real-life clinical practice, it is essential to prioritize the patient's safety and well-being, and to consider the potential risks and benefits of the medication, as well as any potential interactions with other medications, as seen in studies such as 2 and 1.