From the Guidelines
Eliquis (apixaban) is not typically associated with weight gain as a side effect, and most patients taking this medication do not experience changes in weight directly attributable to it. The provided evidence does not directly link Eliquis to weight gain, and the studies focus more on its efficacy and safety in preventing stroke and systemic embolism in patients with atrial fibrillation rather than its effects on weight. For instance, the study published in 2012 1 compares different oral antithrombotics, including apixaban, but does not mention weight gain as a side effect. Similarly, the 2014 guideline for the management of patients with atrial fibrillation 1 discusses the use of apixaban in this context but does not address weight gain.
If you notice weight gain while taking Eliquis, it's more likely related to other factors such as:
- Reduced physical activity, which might occur during recovery from a medical condition
- Other medications you may be taking concurrently
- Changes in your diet or lifestyle Some patients may experience fluid retention while taking anticoagulants, but this is not a common side effect specific to Eliquis, as noted in the context of other anticoagulants and their effects on fluid retention and weight gain 1.
It's essential to discuss any concerns about weight changes with your healthcare provider rather than discontinuing the medication, as stopping anticoagulant therapy without medical supervision can increase your risk of dangerous blood clots. Your doctor can evaluate whether your weight gain might be related to your underlying condition or other medications and suggest appropriate management strategies while maintaining necessary anticoagulation therapy.
From the Research
Eliquis and Weight Gain
- There is no direct evidence in the provided studies that suggests Eliquis (apixaban) causes weight gain.
- The studies focus on the effectiveness and safety of apixaban in patients with various conditions, such as atrial fibrillation, venous thromboembolism, and obesity 2, 3, 4.
- One study examines the pharmacokinetics of apixaban in low-weight patients with cancer-associated thrombosis, but it does not mention weight gain as a side effect 5.
- Another study reviews the literature on the use of direct oral anticoagulants (DOACs), including apixaban, in patients with high body weight or body mass index, but it does not discuss weight gain as a potential issue 6.
- Overall, the available evidence does not provide a clear answer to the question of whether Eliquis causes weight gain, as this topic is not addressed in the provided studies.