From the Research
To lower GLP-1 levels in the blood, focus on dietary modifications and lifestyle changes, as there is no direct medication or method to decrease GLP-1 levels, and reducing the need for its secretion is the most prudent approach. The most recent and highest quality study on GLP-1 receptor agonists was published in 2025 1, which highlights the role of GLP-1 in glucose homeostasis and its potential therapeutic benefits in various conditions, but does not provide direct evidence on lowering GLP-1 levels. However, based on the understanding of GLP-1 secretion and action, the following strategies can be employed:
- Reduce carbohydrate intake, particularly refined carbs and sugars, as these stimulate GLP-1 secretion from intestinal L-cells.
- Adopt a lower-carb diet with more proteins and healthy fats, which trigger less GLP-1 release.
- Intermittent fasting may help as GLP-1 increases after meals, so extending the time between eating can reduce overall levels.
- Regular exercise, particularly strength training and high-intensity interval training, can improve insulin sensitivity and potentially reduce the need for high GLP-1 levels.
- Maintain adequate hydration and ensure sufficient sleep, as sleep deprivation can disrupt hormone balance. Some key points to consider:
- GLP-1 plays beneficial roles in blood sugar regulation and appetite control, so lowering it should be approached cautiously and ideally under medical supervision, especially if you have diabetes or other metabolic conditions.
- If you're taking medications that increase GLP-1 (like certain diabetes medications), consult your healthcare provider before making changes.
- The use of GLP-1 receptor agonists, as discussed in studies such as 2 and 3, is for increasing GLP-1 activity, not decreasing it, and is used in the management of type 2 diabetes and other conditions. It's essential to prioritize morbidity, mortality, and quality of life when considering any changes to GLP-1 levels, and to consult with a healthcare provider before making any significant changes to diet, exercise, or medication regimen.