Can the Medtronic (medtronic) 780G insulin pump system target a blood glucose level of greater than 150 milligrams per deciliter (mg/dL), specifically hyperglycemia?

From the Guidelines

No, the Medtronic 780G insulin pump system does not allow for temporary targets above 150 mg/dL, and based on the most recent evidence, targets should be set between 100-150 mg/dL to maintain optimal glucose control and minimize the risk of hypoglycemia and other complications 1. The system's capabilities are designed to maintain glucose levels within a healthy range, and sustained levels above 150 mg/dL are generally considered above optimal targets for long-term diabetes management. Some studies suggest that more stringent goals, such as <140 mg/dL, may be appropriate for selected patients, as long as this can be achieved without significant hypoglycemia 1. However, the most recent guidelines recommend treating persistent hyperglycemia, generally defined as two serial BG concentrations greater than or equal to 10 mmol/L (180 mg/dL), and initiating insulin therapy with assiduous monitoring to avoid or rapidly identify hypoglycemia 1. Key points to consider when setting targets with the Medtronic 780G include:

• The primary purpose of the system is to maintain glucose levels within a healthy range
• Sustained levels above 150 mg/dL are generally considered above optimal targets for long-term diabetes management
• More stringent goals may be appropriate for selected patients, but must be achieved without significant hypoglycemia
• The system's capabilities can be used to adjust targets and insulin delivery as needed, such as during exercise or illness. If you frequently need higher targets for specific medical reasons, this should be discussed with your healthcare provider, as the Medtronic 780G might not be the most suitable pump system for your particular needs. In terms of specific recommendations, the most recent evidence suggests that:
• Insulin therapy should be initiated for treatment of persistent hyperglycemia starting at a threshold ≥180 mg/dL (10.0 mmol/L) 1
• A target glucose range of 140–180 mg/dL (7.8–10.0 mmol/L) is recommended for the majority of critically ill and non-critically ill patients 1.

From the Research

Temporary Target with Medtronic 780G

• The Medtronic 780G system allows for a temporary target (TT) to be set, which can be useful in certain situations such as exercise or illness 2.
• The TT feature can be set to a glucose target of 150 mg/dL, which is higher than the standard target range of 70-180 mg/dL 2.
• Studies have shown that using the TT feature with the Medtronic 780G system can be safe and effective in maintaining glycemic control during exercise 3.
• In one study, the use of TT with the Medtronic 780G system was compared to suspension of insulin infusion (SII) during aerobic exercise, and no significant differences were found in hypoglycemic events or CGM metrics between the two groups 3.
• However, the study did find that the use of TT resulted in better glycemic profiles in the early phase of exercise, with improved time in range (TIR) and reduced time above range (TAR) 3.

Setting a Temporary Target Greater than 150 mg/dL

• There is limited information available on setting a temporary target greater than 150 mg/dL with the Medtronic 780G system.
• The studies available do not specifically address the safety and efficacy of setting a temporary target greater than 150 mg/dL 3, 2.
• However, it is worth noting that the American Diabetes Association recommends a target glucose range of 70-180 mg/dL for most adults with diabetes, and setting a temporary target greater than 150 mg/dL may not be necessary or recommended in most cases 4.