From the Research
Urine Detection Time for Hydrocodone
The urine detection time for hydrocodone can vary depending on several factors, including the dose administered and the individual's metabolism.
- According to a study published in 2013 1, the detection time for hydrocodone in urine was approximately 28 hours at a cutoff concentration of 50 ng/mL.
- Another study published in 2012 2 found that hydrocodone was detectable in urine for up to 24 hours after a single 10 mg dose, with peak concentrations occurring between 3:30 and 7:00 hours post-dose.
- A study from 1995 3 reported that hydrocodone was detectable in urine for 6-24 hours after a single dose, with peak concentrations occurring within 8 hours after drug administration.
- It's worth noting that the detection time for hydrocodone can be influenced by the presence of its metabolites, such as hydromorphone and norhydrocodone, which can also be detected in urine 1, 2, 3.
- The detection of hydrocodone in urine can be affected by various factors, including the sensitivity of the testing method and the individual's renal function 1, 3.
Factors Affecting Detection Time
Several factors can affect the detection time of hydrocodone in urine, including:
- Dose and frequency of administration: Higher doses and more frequent administration can lead to longer detection times 1, 2.
- Individual metabolism: Variations in individual metabolism can affect the rate at which hydrocodone is eliminated from the body 1, 2.
- Renal function: Impaired renal function can lead to longer detection times due to reduced elimination of the drug 1, 3.
- Testing method: The sensitivity of the testing method can affect the detection time, with more sensitive methods detecting the drug for longer periods 1, 3.
Comparison with Other Specimens
Hydrocodone and its metabolites can also be detected in other specimens, such as oral fluid 4.
- A study published in 2014 4 found that the detection rate of hydrocodone and its metabolites in oral fluid was lower than in urine, with median concentrations of 122 ng/mL for hydrocodone and 7.7 ng/mL for norhydrocodone.
- The study also found that the geometric median metabolic ratio of norhydrocodone to hydrocodone was lower in oral fluid than in urine, suggesting differences in the metabolism and excretion of hydrocodone between the two specimens 4.