Can Istodax (romidepsin) cause peripheral edema?

From the FDA Drug Label

Serious adverse reactions reported in >2% of patients in Study 2 were ... edema (5%)

• Edema is listed as a serious adverse reaction in Study 2, occurring in 5% of patients.
• The FDA drug label does not specify whether the edema is peripheral or not, but it does mention edema as a serious adverse reaction.
• Based on the available information, it can be inferred that Istodax (romidepsin) may cause edema, but the specific type of edema (e.g., peripheral) is not explicitly stated 1.

From the Research

Adverse Events Associated with Romidepsin

• The most common adverse events associated with romidepsin are hematologic or asthenic in nature, including leukopenia, lymphopenia, granulocytopenia, thrombocytopenia, fatigue, and anemia 2, 3, 4.
• Grade 3 or 4 treatment-emergent adverse events occurring in ≥ 30% of patients in the Ro-CHOP arm included thrombocytopenia, neutropenia, anemia, and leukopenia 5.
• Infections were reported in 34% of patients, and most grade 3 and 4 adverse events were hematological (35%) 6.

Peripheral Edema

• There is no direct mention of peripheral edema as an adverse event associated with romidepsin in the provided studies 2, 3, 5, 4, 6.