What are the potential side effects of Pyrantel (antiparasitic medication) pamoate?

Pyrantel Pamoate Side Effects

Pyrantel pamoate is generally well-tolerated with mild gastrointestinal side effects being most common, including abdominal cramps, nausea, vomiting, diarrhea, headache, and dizziness. 1

Common Side Effects

• Gastrointestinal symptoms are the most frequently reported adverse effects, including abdominal cramps, nausea, vomiting, and diarrhea 1
• Headache and dizziness occur occasionally after administration 1
• In large field studies involving over 4,000 treatments, only 8 cases (0.2%) reported side effects such as abdominal pain and diarrhea, demonstrating excellent tolerability 2

Clinical Tolerability Profile

• Both suspension and tablet formulations are well-tolerated in single and multiple-dose regimens 3
• The medication is considered highly safe even with repeated bimonthly administration over extended periods (up to 18 months) 2
• No drug-related adverse clinical or neurological health events were observed in veterinary field trials involving 178 animals 4

Rare but Serious Adverse Effects

• Acute pancreatitis has been reported as a potential adverse effect in at least one case report, though causality could not be definitively established 5
• This rare complication may be more likely in patients with underlying liver dysfunction or elevated lipase activity 5

Special Precautions

• Pregnancy: Do not take unless directed by a physician 1
• Liver disease: Do not take unless directed by a physician 1
• Accidental overdose: Seek immediate professional assistance or contact a Poison Control Center 1

Important Clinical Considerations

• Most side effects, when they occur, are self-limited and do not require discontinuation of therapy 1
• If symptoms persist, consult a physician 1
• Exercise caution when administering to patients with suspected underlying hepatic disorders, as this may increase risk of rare complications 5