INR Goal for ON-X Valves in Both Aortic and Mitral Positions
For a patient with ON-X mechanical valves in both the aortic and mitral positions, target an INR of 3.0 (range 2.5-3.5) plus aspirin 75-100 mg daily.
Rationale for This Recommendation
The presence of a mechanical valve in the mitral position is the dominant risk factor that determines anticoagulation intensity, regardless of valve type. Here's why:
Mitral Position Drives Higher INR Requirements
Mechanical mitral valves carry significantly higher thromboembolic risk (0.9% per year) compared to aortic valves (0.5% per year), and double valve replacement increases this risk to 1.2% per year 1.
All mechanical mitral valves require INR 3.0 (range 2.5-3.5) according to ACC/AHA guidelines, regardless of valve design 1, 2.
The American College of Chest Physicians specifically recommends INR target 3.0 (range 2.5-3.5) for patients with mechanical valves in both aortic and mitral positions 1.
ON-X Valve Considerations Do Not Override Mitral Position Risk
While the ON-X valve has lower thrombogenicity in the aortic position alone:
Lower INR targets (1.5-2.0 or 2.0-2.5) for ON-X valves are only validated for isolated aortic valve replacement without additional risk factors 1, 3, 4.
The PROACT Mitral trial tested lower-dose warfarin (INR 2.0-2.5) in ON-X mitral valves but failed to demonstrate noninferiority compared to standard dosing (INR 2.5-3.5), with composite event rates of 11.9% versus 12.0% per patient-year 5.
Having a mitral mechanical valve is itself classified as a high-risk factor that mandates higher INR targets 1, 2.
Aspirin Addition
Add aspirin 75-100 mg daily to warfarin therapy for all patients with mechanical valves, particularly those with additional risk factors like double valve replacement 1, 2.
The combination of aspirin plus warfarin reduces mortality (RR 0.58) and thromboembolism (RR 0.42) compared to warfarin alone, with only modest increase in bleeding risk (RR 1.44) 1.
Critical Pitfalls to Avoid
Do Not Use Aortic-Only ON-X Protocols
The lower INR ranges (1.5-2.0) approved for isolated ON-X aortic valves are contraindicated when a mitral mechanical valve is present 1, 2.
Case reports document thromboembolic strokes occurring with ON-X aortic valves even at INR 2.4, requiring escalation to INR 2.5-3.5 6.
Maintain Therapeutic Range Consistently
Patient compliance is challenging with higher INR goals: patients with target INR 3.0-4.5 were only in therapeutic range 44.5% of the time versus 74.5% for INR 2.0-3.5 targets 1.
Consider home INR monitoring to improve time in therapeutic range 5, 3.
If Thromboembolism Occurs Despite Therapeutic INR
Increase INR goal from 3.0 (range 2.5-3.5) to 4.0 (range 3.5-4.0) for mechanical mitral valves experiencing stroke while in therapeutic range 2.
Ensure aspirin 75-100 mg daily is added if not already prescribed 2.
Reassess for other hypercoagulable conditions 6.
Summary Algorithm
- Confirm valve positions: Both aortic and mitral = double mechanical valve replacement
- Target INR 3.0 (range 2.5-3.5) based on mitral position 1, 2
- Add aspirin 75-100 mg daily 1, 2
- Monitor INR closely with goal of >70% time in therapeutic range 1
- If breakthrough thromboembolism occurs: escalate to INR 4.0 (range 3.5-4.0) 2