From the Research
Mounjaro (tirzepatide) has been associated with pleural effusion in a rare case report, but it is not a common side effect listed in clinical trials or post-marketing surveillance. The most common side effects of Mounjaro include gastrointestinal issues like nausea, vomiting, diarrhea, decreased appetite, and abdominal pain. However, patients with certain pre-existing conditions, particularly heart failure, kidney disease, or liver problems, may be at higher risk for fluid retention issues while taking medications that affect metabolism.
Key Points to Consider
- A case report published in Cureus in 2024 1 described a patient who developed acute pancreatitis and subsequent pleural effusion after initiating tirzepatide, highlighting the potential for rare but serious adverse effects.
- Clinical trials, such as the one published in The New England Journal of Medicine in 2025 2, have not reported pleural effusion as a common side effect of tirzepatide, but have noted improvements in cardiovascular outcomes and health status in patients with heart failure and obesity.
- The medication's labeling and post-marketing surveillance have not identified pleural effusion as a common side effect, but patients should be monitored for signs of fluid retention and other potential adverse effects.
Recommendations for Patients
- If you experience symptoms such as shortness of breath, chest pain, or difficulty breathing while taking Mounjaro, you should seek immediate medical attention as these could indicate a serious condition requiring evaluation.
- It's always important to discuss any concerns about medication side effects with your healthcare provider, who can evaluate your specific medical history and risk factors.
- Patients with pre-existing conditions, such as heart failure or kidney disease, should be closely monitored while taking Mounjaro to minimize the risk of adverse effects.