Estrace Tube Contents
A standard tube of Estrace (estradiol vaginal cream) contains 42.5 grams of cream. 1
Key Product Information
Cream amount per application: The standard dose is 0.5 grams of cream per application, which delivers 15 μg of estradiol when using the 0.003% formulation 2, 3
Total applications per tube: A 42.5-gram tube provides approximately 85 applications when using the standard 0.5-gram dose 1
Clinical Context for Dosing
Initial treatment phase: Apply 0.5 grams (one applicator dose) intravaginally once daily for 2 weeks 2, 3
Maintenance phase: After the initial period, reduce frequency to 2-3 applications per week 2, 3
The twice-weekly maintenance regimen (0.5 grams per application) has demonstrated significant efficacy in treating vulvovaginal atrophy symptoms including vaginal dryness and dyspareunia 3, 4
At this maintenance frequency, a single 42.5-gram tube would last approximately 42-43 weeks (roughly 10-11 months) 1
Important Safety Consideration
Systemic absorption occurs: Despite being applied vaginally, estradiol cream results in rapid, efficient, and sustained systemic absorption 5. However, low-dose vaginal estrogen preparations (0.003% formulation) deliver high local concentrations with minimal systemic absorption, eliminating the need for concurrent progestin therapy even in women with an intact uterus when used at recommended doses 1