What medication can be used to treat urinary incontinence in dogs?

Medication for Urinary Incontinence in Dogs

For urinary incontinence in dogs, phenylpropanolamine (PROIN or PROIN ER) is the FDA-approved medication of choice, demonstrating effectiveness in controlling incontinence due to urethral sphincter hypotonus in both spayed females and neutered males. 1

FDA-Approved Treatment

• Phenylpropanolamine (PROIN ER) is specifically approved for control of urinary incontinence due to urethral sphincter hypotonus in dogs 1

• The medication was proven effective in a multi-center study of 119 dogs (113 spayed females and 6 neutered males, aged 1-16 years, weighing 4.9-81.8 kg) 1

• In the clinical trial, 72.1% of dogs maintained the same level of incontinence control when switched from twice-daily PROIN Chewable Tablets to once-daily PROIN ER, while 18.3% showed improvement 1

• Owner assessment at the end of the 28-day study period showed "improved" control for 12.5% of dogs, "stayed the same" for 86.5%, and "worsened" for only 1% 1

Dosing Considerations

• PROIN ER offers the convenience of once-daily dosing compared to the twice-daily regimen required for PROIN Chewable Tablets 1

• The medication is effective across a wide weight range (4.9-81.8 kg), making it suitable for various dog breeds and sizes 1

Clinical Context

• Urinary incontinence in dogs is most commonly due to urethral sphincter hypotonus, particularly in spayed female dogs 1

• The condition responds well to phenylpropanolamine therapy, with the majority of dogs achieving adequate control of incontinence episodes 1