Dextroamphetamine 10 mg Formulation Availability
Yes, dextroamphetamine is available in a 10 mg formulation, specifically as Dexedrine Spansule (sustained-release capsule), with the starting dose being 10 mg once daily in the morning. 1
Available Formulations and Dosing
Immediate-Release Formulation
- Dextroamphetamine immediate-release tablets typically start at 5 mg, given once or twice daily 2
- For narcolepsy in patients 12 years and older, the starting dose is 10 mg daily, with increases of 10 mg at weekly intervals until optimal response is achieved 1
- The immediate-release form is dosed at 4-6 hour intervals throughout the day 1
Sustained-Release Formulation (Spansule)
- Dexedrine Spansule starts at 10 mg once daily in the morning 2
- This formulation can be increased by 5 mg increments as needed 2
- The Spansule is commonly combined with immediate-release dextroamphetamine for flexible dosing and breakthrough symptom coverage 3
Clinical Context for 10 mg Dosing
ADHD Treatment
- For ADHD in children 6 years and older, the starting dose is 5 mg once or twice daily, with weekly increases of 5 mg until optimal response 1
- The 10 mg dose would represent a titrated dose after initial treatment establishment 2
Narcolepsy Treatment
- For narcolepsy in patients 12 years and older, 10 mg daily is the recommended starting dose 1
- Total daily doses for narcolepsy typically range from 5-60 mg depending on individual response 1
- Dextroamphetamine is conditionally recommended as a second-line agent for narcolepsy, reserved for cases where first-line treatments (modafinil, solriamfetol, sodium oxybate, pitolisant) are ineffective or contraindicated 3, 4
Important Prescribing Considerations
- Dextroamphetamine is a DEA Schedule II controlled substance with high potential for abuse and dependence 3, 4
- Late evening doses should be avoided due to insomnia risk 1
- Common adverse effects include appetite suppression, weight loss, irritability, and cardiovascular effects 3, 4
- Regular monitoring for signs of tolerance, abuse behaviors, and cardiovascular effects is essential 3, 4