What is the dosing equivalent between clonazepam and Ativan (lorazepam)?

From the Research

Dosing Equivalence

The dosing equivalence between clonazepam and Ativan (lorazepam) can be determined from the following studies:

• In a study comparing the efficacy and tolerability of lorazepam and clonazepam in the treatment of status epilepticus, lorazepam 4 to 10 mg IV was compared to clonazepam 1 mg IV 1.
• A case study reported that an equivalent dose of lorazepam had ameliorated panic attacks in a patient, but clonazepam was more effective in resolving obsessive compulsive disorder (OCD) symptoms 2.

Key Findings

• The study comparing lorazepam and clonazepam in status epilepticus suggests that 4 to 10 mg of lorazepam is equivalent to 1 mg of clonazepam 1.
• However, there is limited information available on the exact dosing equivalence between clonazepam and lorazepam for other indications.
• Other studies provide information on the pharmacokinetics and pharmacodynamics of lorazepam, but do not directly address the dosing equivalence with clonazepam 3, 4, 5.