What is the differential diagnosis for a hamstring (muscle in the posterior thigh) injury?

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Last updated: April 17, 2025View editorial policy

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Differential Diagnosis for Hamstring Injury

  • Single most likely diagnosis
    • Hamstring strain: This is the most common cause of hamstring injury, typically occurring during sprinting or other high-speed activities. It is characterized by a sudden onset of pain and swelling in the posterior thigh.
  • Other Likely diagnoses
    • Hamstring tendinopathy: This condition involves chronic inflammation of the hamstring tendons, often caused by repetitive strain or overuse. It presents with gradual onset of pain and stiffness in the posterior thigh.
    • Hamstring contusion: A direct blow to the posterior thigh can cause a hamstring contusion, leading to pain, swelling, and bruising.
    • Proximal hamstring avulsion: This injury occurs when the hamstring tendons are pulled off the bone, often resulting in severe pain and limited mobility.
  • Do Not Miss diagnoses
    • Compartment syndrome: Although rare, compartment syndrome is a potentially life-threatening condition that can occur after a hamstring injury. It is characterized by severe pain, swelling, and numbness in the affected limb.
    • Vascular injury: A hamstring injury can occasionally be associated with damage to the nearby blood vessels, which can lead to serious complications if left untreated.
  • Rare diagnoses
    • Hamstring rupture: A complete tear of the hamstring muscles or tendons is a rare but serious injury that requires prompt medical attention.
    • Popliteal artery entrapment syndrome: This rare condition involves compression of the popliteal artery, which can cause pain, numbness, and weakness in the affected limb.
    • Peripheral nerve injury: Direct trauma or compression of the nearby nerves can cause numbness, tingling, or weakness in the affected limb.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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