What is the half-life of St. John's wort's effect on serotonin reuptake?

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Dainyal Siddiqui, MD

Internal Medicine

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Manuel Jimenez, MD

Cardiology

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Franz Pierre-Louis, MD

Infectious Disease

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Last updated: February 15, 2025 • View editorial policy

From the Research

Half-Life of St. John's Wort's Effect on Serotonin Reuptake

  • The half-life of St. John's wort's effect on serotonin reuptake is not explicitly stated in the provided studies 1, 2, 3, 4, 5.
  • However, the studies suggest that St. John's wort inhibits serotonin reuptake, with hyperforin being the major constituent responsible for this effect 2, 3, 4, 5.
  • The IC50 values (concentration producing half-maximal inhibition) for serotonin reuptake inhibition were found to be between 3.07 and 17.9 microg extract mL(-1) in different St. John's wort products 5.
  • The mechanism of action of St. John's wort in inhibiting serotonin reuptake is thought to be related to the elevation of free intracellular Na+1, similar to the effect of monensin 2.
  • The studies do not provide information on the duration of action or half-life of St. John's wort's effect on serotonin reuptake, but rather focus on its efficacy and mechanism of action 1, 2, 3, 4, 5.

References

1
Research

About the cover: St. John's wort.

Journal of the Society for Integrative Oncology, 2006

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