Understanding the Question
I need to clarify that "GDR" (Gastric Decompression and Removal) does not appear to be a standard medical abbreviation or procedure in the provided evidence or in standard medical practice. The evidence provided focuses entirely on sertraline use in depression, anxiety disorders, and cardiovascular conditions, with no mention of any gastrointestinal decompression procedures or contraindications related to such procedures.
Possible Interpretations
If you are asking about a specific medical procedure abbreviated as "GDR," this term is not recognized in standard medical literature or the evidence provided 1.
What the Evidence Actually Addresses
The provided evidence comprehensively covers:
- Sertraline's indications: Major depressive disorder, obsessive-compulsive disorder, panic disorder, posttraumatic stress disorder, social anxiety disorder, and premenstrual dysphoric disorder 2
- Sertraline's contraindications: Use with MAOIs, pimozide, or disulfiram (with liquid formulation) 2
- Sertraline's safety profile: Including cardiovascular safety, bleeding risks, and drug interactions 2, 3
Actual Contraindications to Sertraline
The FDA label clearly states that sertraline should NOT be used in patients who 2:
- Are allergic to sertraline or its ingredients
- Take pimozide (risk of serious heart problems)
- Take MAOIs or have taken them within 2 weeks
- Take disulfiram/Antabuse (if using liquid sertraline formulation due to alcohol content)
When Sertraline Requires Caution
Sertraline should be used cautiously but is not contraindicated in patients with 2:
- Recent myocardial infarction or unstable heart disease (though studies show safety in this population) 2
- Seizure disorders (introduce with care) 2
- Liver or kidney impairment (dose adjustment may be needed) 2
- Bleeding disorders or concurrent use of anticoagulants/NSAIDs 2
Request for Clarification
Please clarify what "GDR" refers to in your clinical context, as this abbreviation does not correspond to any standard medical procedure that would have contraindications related to sertraline use. If you meant a different procedure or abbreviation, providing the full name would allow for an accurate, evidence-based response.