From the Research
There is no known significant interaction between testosterone cream and the antibiotics rifaximin or neomycin that would affect testosterone absorption. Testosterone cream is absorbed through the skin directly into the bloodstream, bypassing the gastrointestinal tract where these antibiotics primarily work. Rifaximin is a non-absorbable antibiotic that stays within the gut and has minimal systemic absorption, while neomycin is also poorly absorbed from the intestine when taken orally. Since these antibiotics have limited systemic distribution and do not significantly alter skin permeability, they should not interfere with the transdermal absorption of testosterone.
Key Points to Consider
- The absorption of testosterone cream is not significantly affected by rifaximin or neomycin, as these antibiotics have limited systemic distribution and do not alter skin permeability 1, 2.
- Testosterone cream is absorbed through the skin directly into the bloodstream, bypassing the gastrointestinal tract where these antibiotics primarily work.
- Rifaximin and neomycin are poorly absorbed from the intestine when taken orally, which further reduces the likelihood of an interaction with testosterone cream absorption.
- However, if you notice any changes in testosterone effects while taking these antibiotics, consult your healthcare provider, as individual responses can vary.
- It's always important to inform all your healthcare providers about all medications you're taking, including topical hormones and antibiotics, to monitor for any unexpected interactions 3, 4.
Clinical Implications
- The lack of significant interaction between testosterone cream and rifaximin or neomycin suggests that patients can continue to use testosterone cream as prescribed while taking these antibiotics.
- Healthcare providers should still monitor patients for any changes in testosterone effects or unexpected interactions, especially in patients with underlying medical conditions or taking multiple medications.
- Further studies are needed to fully understand the potential interactions between testosterone cream and other medications, including antibiotics.