From the Guidelines
Borage oil is not recommended for the treatment of atopic dermatitis due to lack of supportive evidence. The use of borage oil has been evaluated in two randomized controlled trials (RCTs), which found no improvement in key outcomes compared to placebo 1. This suggests that borage oil may not be effective in reducing inflammation or improving symptoms in patients with atopic dermatitis. Some key points to consider when evaluating the use of borage oil include:
- The proposed mechanism of action of borage oil is related to its gamma-linolenic acid (GLA) content, which is thought to have anti-inflammatory properties.
- However, the majority of data from RCTs evaluating the use of oral borage oil and other supplements, such as evening primrose oil, have found no benefit in the treatment of atopic dermatitis 1.
- As a result, borage oil should not be recommended as a treatment option for atopic dermatitis, and other evidence-based treatments should be prioritized instead. Key considerations for clinicians include:
- The lack of supportive evidence for the use of borage oil in atopic dermatitis.
- The potential for borage oil to interact with other medications, such as blood-thinning agents.
- The importance of choosing high-quality supplements that specify GLA content and are free from harmful compounds, if borage oil is still considered for use in other contexts.
From the Research
Borage Oil and Gamma-Linolenic Acid (GLA)
- Borage oil is a rich source of gamma-linolenic acid (GLA), an omega-6 fatty acid with potential anti-inflammatory effects 2, 3.
- GLA is produced in the body from linoleic acid and can be further metabolized to dihomogamma linolenic acid (DGLA), which has anti-inflammatory properties 2, 4.
Health Benefits of GLA
- GLA supplementation has been shown to have potential therapeutic benefits in the treatment of various conditions, including diabetic neuropathy, eczema, cyclic mastalgia, rheumatoid arthritis, osteoporosis, and ADHD 5.
- GLA may also have anti-inflammatory and antiproliferative effects, which could be beneficial in preventing or treating chronic diseases such as cancer, heart disease, and Alzheimer's disease 2, 4.
Effects of GLA Supplementation on Fatty Acid Composition
- GLA supplementation can increase the content of DGLA in cell membranes and plasma lipids, which may lead to anti-inflammatory effects 3, 4.
- The effects of GLA supplementation on fatty acid composition may vary depending on the individual's race and genetic background, as well as the dosage and duration of supplementation 6.
Potential Applications of Borage Oil and GLA
- Borage oil and GLA may be used as a dietary supplement to support health and prevent disease, particularly in individuals with a high risk of chronic inflammation or oxidative stress 2, 5.
- Further research is needed to fully understand the potential benefits and risks of borage oil and GLA supplementation, as well as the optimal dosage and duration of treatment 3, 6.