Amlodipine Administration Timing
Amlodipine can be taken with or without food—there is no requirement to take it on an empty stomach. 1
Official FDA Guidance
The FDA-approved prescribing information explicitly states: "Take amlodipine besylate tablets, USP once a day, with or without food." 1 This provides clear flexibility in administration timing based on patient preference and convenience.
Practical Administration Recommendations
For optimal adherence, take amlodipine at the same time each day, such as with breakfast, dinner, or at bedtime. 1 The consistent timing matters more than whether food is present, as this helps establish a routine and reduces the likelihood of missed doses.
Key Pharmacokinetic Considerations
- Amlodipine has a very long half-life of 30-50 hours, which supports true once-daily dosing with sustained 24-hour blood pressure control. 2, 3, 4
- The drug has high oral bioavailability (60-80%) regardless of food intake. 4
- Peak plasma concentrations occur 6-8 hours after dosing, with gradual onset of effect over 4-8 hours. 4
- Plasma drug concentration fluctuation between doses is only 20-25% with once-daily dosing. 4
Important Contrast with Other Medications
This differs from certain sedative-hypnotics (like benzodiazepine receptor agonists), which should be taken on an empty stomach to maximize effectiveness. 5 Amlodipine does not have this requirement—food does not meaningfully impact its absorption or efficacy.
Missed Dose Management
If a dose is missed, take it as soon as remembered. However, do not take amlodipine if more than 12 hours have passed since the missed dose—instead, wait and take the next dose at the regular scheduled time. 1 Never double up on doses.