What is the summary of the NOTABLE (New Oral Treatment And Lowering of Blood Pressure Effectiveness) trial for managing chronic disease in patients with impaired renal function and multiple comorbidities?

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The NOTABLE Trial Does Not Exist

I cannot provide a summary of the "NOTABLE trial" (New Oral Treatment And Lowering of Blood Pressure Effectiveness) because no such trial exists in the medical literature or in the evidence provided.

The evidence base includes multiple major blood pressure and chronic kidney disease trials, but none are named NOTABLE:

  • SPRINT (Systolic Blood Pressure Intervention Trial) - examined intensive BP control (<120 mmHg vs <140 mmHg) in patients with CKD 1
  • ACCORD (Action to Control Cardiovascular Risk in Diabetes) - studied BP targets in diabetes patients 1
  • CREDENCE (Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation) - evaluated canagliflozin in diabetic kidney disease 1
  • DAPA-CKD (Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease) - examined dapagliflozin in CKD patients 1, 2
  • FIDELIO-DKD (Finerenone in Reducing Kidney Failure and Disease Progression in Diabetic Kidney Disease) - studied finerenone in diabetic kidney disease 1
  • EVOLVE - evaluated cinacalcet in dialysis patients with secondary hyperparathyroidism 1
  • PRIMO and OPERA - examined paricalcitol in CKD-mineral bone disorder 1

If you are seeking information about blood pressure management in CKD patients with multiple comorbidities and impaired renal function, the most relevant trial is SPRINT 1. If you meant a different trial name or can provide additional details, please clarify so I can provide accurate information.

References

1
Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

2
Guideline

Dapagliflozin Dosing and Safety Considerations

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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