What is the typical quantity of atorvastatin (a statin) tablets dispensed at once for a patient with hypercholesterolemia or at risk of cardiovascular disease?

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Atorvastatin Dispensing Quantity

Atorvastatin is typically dispensed as a 30-day supply (30 tablets) for once-daily dosing, though 90-day supplies (90 tablets) are commonly provided for maintenance therapy to improve adherence and reduce costs. 1

Standard Dispensing Practice

  • Atorvastatin is administered once daily, with or without food, making the dispensing quantity directly tied to the duration of therapy prescribed 1
  • The FDA-approved dosing regimen specifies once-daily administration across all dose strengths (10 mg, 20 mg, 40 mg, and 80 mg) 1
  • Initial prescriptions commonly provide 30 tablets (one month supply) to allow for early assessment of tolerability and efficacy 1

Monitoring and Refill Considerations

  • LDL-C should be assessed as early as 4 weeks after initiating therapy, which aligns with the typical 30-day initial dispensing quantity 1
  • After the initial assessment period, 90-day supplies are frequently dispensed for stable patients to improve medication adherence and reduce pharmacy visits 2
  • The American Diabetes Association recommends checking lipid panels 4-12 weeks after initiation or dose changes, supporting the 30-day initial supply approach 2

Dose-Specific Dispensing

  • All atorvastatin doses (10-80 mg) are taken once daily, so the number of tablets dispensed equals the number of days of therapy regardless of dose strength 1
  • For patients requiring dose titration, initial 30-day supplies allow for reassessment before committing to larger quantities 3
  • The dose range of 10-80 mg daily means patients receive the same number of tablets but at different strengths depending on their LDL-C reduction needs 2, 1

Cost and Adherence Factors

While some research has explored alternate-day dosing to reduce costs 4, 5, the FDA-approved regimen and all major guidelines specify daily administration 1, 2. Dispensing practices should follow the approved once-daily dosing schedule.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Efficacy and safety of atorvastatin 10 mg every other day in hypercholesterolemia.

Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2002

Research

Efficacy of atorvastatin when not administered daily.

Arquivos brasileiros de cardiologia, 2007

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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