From the Research
The maximum weight-based dosing for fluoxetine in dogs for anxiety management is 1.5 mg/kg once daily, as supported by the most recent and highest quality study available 1. This dosing is based on a study that investigated the clinical effectiveness of fluoxetine combined with a behavior modification program for the treatment of canine dominance-related aggression, which is a common anxiety-related disorder in dogs. The study found that fluoxetine at a dose of 1.5 mg/kg/day was effective in controlling canine aggression over a six-month period, and that norfluoxetine levels seemed reliable in predicting clinical efficacy.
Key Points to Consider
- Fluoxetine, a selective serotonin reuptake inhibitor (SSRI), works by increasing serotonin levels in the brain, which helps regulate mood and anxiety.
- The medication should be given consistently at the same time each day, and treatment should not be stopped abruptly but rather tapered gradually under veterinary supervision.
- Fluoxetine therapy is most effective when combined with appropriate behavior modification techniques and environmental management strategies to address the underlying causes of anxiety.
- Side effects may include lethargy, decreased appetite, gastrointestinal upset, and rarely agitation, as noted in various studies, including one that used a dose of 1.0 mg/kg every 24 h for 10 weeks 2.
Important Considerations for Treatment
- It's essential to start with a lower dose and gradually increase as needed based on the dog's response and tolerance.
- The treatment should be tailored to the individual dog's needs, taking into account the severity of the anxiety disorder and the dog's overall health.
- Regular monitoring and follow-up with a veterinarian are crucial to ensure the effectiveness of the treatment and to minimize potential side effects.