Maximum Daily Dose of Robaxin (Methocarbamol)
The maximum daily dose of Robaxin (methocarbamol) is 8 grams per day for severe conditions during the first 48-72 hours, after which the dose should be reduced to approximately 4 grams per day for maintenance therapy. 1
Initial Dosing (First 48-72 Hours)
- Standard recommendation: 6 grams daily for the initial treatment period 1
- For severe musculoskeletal conditions: up to 8 grams daily may be administered during the acute phase 1
- This higher dosing is specifically intended for short-term use only during the most severe symptom period 1
Maintenance Dosing (After 72 Hours)
- Reduce to approximately 4 grams daily once the acute phase has passed 1
- This maintenance dose provides continued muscle relaxation while minimizing side effects 1
Practical Dosing Schedules
For 500 mg tablets: 1
- Initial: 3 tablets four times daily (6 grams/day)
- Maintenance: 2 tablets four times daily (4 grams/day)
For 750 mg tablets: 1
- Initial: 2 tablets four times daily (6 grams/day)
- Maintenance: 1 tablet every 4 hours OR 2 tablets three times daily (4-4.5 grams/day)
Critical Safety Considerations
- Avoid alcohol completely while taking methocarbamol, as the combination can cause fatal CNS depression due to synergistic sedative-hypnotic effects 2
- Common side effects include drowsiness (which may resolve with dose reduction), mild weakness, and excessive perspiration 3
- The sedative effects are dose-dependent and may impair activities requiring alertness 2
Clinical Pitfalls to Avoid
- Do not exceed 8 grams daily even in severe cases, as this represents the absolute maximum recommended dose 1
- Do not maintain high doses beyond 72 hours without reassessing the need for continued therapy at that level 1
- Screen for alcohol use before prescribing, as concurrent use is contraindicated due to potentially fatal interactions 2