From the Research
The treatment for mononucleosis (mono) primarily focuses on managing symptoms while the body fights the infection, as there is no specific cure. According to the most recent study 1, rest is the most important treatment, with patients needing to limit activities for several weeks until symptoms improve. For pain and fever, over-the-counter medications like acetaminophen (Tylenol) at 650mg every 6 hours or ibuprofen (Advil, Motrin) at 400-600mg every 6-8 hours can help, as suggested by previous studies 2, 3. Staying hydrated is crucial, so drink plenty of fluids. Gargling with warm salt water (1/2 teaspoon salt in 8 ounces of water) can soothe a sore throat. Some key points to consider in the treatment of mono include:
- Avoiding contact sports and heavy lifting for at least 3 weeks from onset of symptoms, or until cleared by a doctor, as mono can cause spleen enlargement which risks rupture with physical trauma 1.
- Avoiding alcohol during recovery since mono affects the liver.
- Most people recover within 2-4 weeks, though fatigue may persist longer.
- The body needs time to develop antibodies against the Epstein-Barr virus that causes mono, and these supportive measures help manage symptoms while your immune system does its work. It's also important to note that current guidelines do not recommend the routine use of antivirals and corticosteroids for the treatment of mono 1. Instead, treatment should focus on managing symptoms and supporting the body's natural recovery process.