Is an ejection fraction (EF) of 72% normal or elevated?

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Last updated: April 18, 2025 • View editorial policy

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From the Guidelines

A 72% ejection fraction is within the normal range, as defined by the American Heart Association, which states that a normal ejection fraction is between 60% to 75%. According to the study published in Circulation in 2001 1, the ejection fraction is the ratio of LV stroke volume to end-diastolic volume, and a value of 72% falls within the normal range. Some key points to consider when evaluating ejection fraction include:

  • The definition of ejection fraction as the ratio of LV stroke volume to end-diastolic volume, as stated in the study 1
  • The normal range for ejection fraction, which is between 60% to 75%, as defined by the American Heart Association in the study 1
  • The fact that a value of 72% is within this normal range, and therefore, is not typically a cause for concern. It's worth noting that while a value of 72% is within the normal range, it's always best to consult with a healthcare provider to determine the best course of action, especially if symptoms are present. However, based on the evidence from the study 1, a 72% ejection fraction is considered normal.

From the Research

Ejection Fraction Normal Range

  • A normal ejection fraction (EF) is typically considered to be between 50% and 70% 2.
  • An EF of 72% is slightly above the normal range, but it is not significantly high 2.

Association with Heart Failure

  • Studies have shown that patients with heart failure and an EF >65% to 70% may have a higher mortality rate 2.
  • However, the relationship between EF and mortality is complex, and other factors such as symptoms, comorbidities, and treatment strategies also play a role [(2,3)].

Hypertrophic Cardiomyopathy

  • In patients with hypertrophic cardiomyopathy (HCM), a low-normal EF (50%-60%) has been associated with adverse outcomes, including heart failure hospitalization and cardiovascular death 4.
  • However, the prognostic significance of a high EF in HCM is not well established 4.

Clinical Implications

  • The clinical implications of an EF of 72% depend on the individual patient's symptoms, medical history, and other factors [(3,5)].
  • Further evaluation and monitoring may be necessary to determine the significance of an EF of 72% in a given patient [(6,5)].

References

3
Research

Clinical characteristics and prognosis of patients with hypertrophic cardiomyopathy and heart failure with preserved ejection fraction.

Clinical research in cardiology : official journal of the German Cardiac Society, 2024

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.