From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
Thorne Research Berberine is the most evidence-based product due to its rigorous quality control standards and third-party testing, as well as its consistent quality and potency based on independent testing results. When considering berberine supplements, it's essential to prioritize products with good manufacturing practices to ensure purity and bioavailability. The recommended dosage for berberine is typically 500mg taken 2-3 times daily (1000-1500mg total daily dose), preferably with meals to improve absorption and reduce potential gastrointestinal side effects 1. For metabolic health benefits, this dosage should be maintained consistently for at least 3 months to evaluate effectiveness. Berberine has been studied for its potential benefits in managing blood glucose levels, improving lipid profiles, and supporting cardiovascular health, with significant effects on blood glucose levels, insulin resistance, blood lipids, body parameters and composition, inflammatory markers, colorectal adenomas, and Helicobacter pylori infections as compared to controls 1.
Some key points to consider when selecting a berberine supplement include:
- Purity and bioavailability of the product
- Good manufacturing practices
- Third-party testing and quality control standards
- Potential interactions with medications, particularly those metabolized by the liver
- Starting with a recommended dosage and maintaining it consistently for at least 3 months to evaluate effectiveness. Other reliable brands include Pure Encapsulations and Integrative Therapeutics, but Thorne's product has particularly consistent quality and potency based on independent testing results. Be aware that berberine may interact with certain medications, particularly those metabolized by the liver, so consulting with a healthcare provider before starting supplementation is advisable 1.