What is the most evidence-based, peer-reviewed weight loss supplement available in Australia, with a focus on supplements supported by clinical trials and approved by the Therapeutic Goods Administration (TGA)?

From the Guidelines

Based on current evidence, there is no clear evidence that dietary supplements are effective for obesity management or weight loss in Australia. Despite widespread marketing and exorbitant claims, several large systematic reviews show that most trials evaluating dietary supplements for weight loss are of low quality and at high risk for bias 1. High-quality published studies show little or no weight loss benefits.

Key Points to Consider

• The most recent and highest quality studies suggest that dietary supplements are not effective for weight loss 1.
• Comprehensive weight loss maintenance programs that provide at least monthly contact with trained interventionists and focus on ongoing monitoring of body weight, nutrition, and behavioral changes are recommended 1.
• Structured, very-low-calorie meals, typically 800–1,000 kcal/day, utilizing high-protein foods and meal replacement products, may increase the pace and/or magnitude of initial weight loss and glycemic improvements compared with standard behavioral interventions 1.
• Vitamin/mineral supplementation may be indicated in cases of documented deficiency, and protein supplements may be indicated as adjuncts to medically supervised weight loss regimens 1.

Recommendation

The most effective approach to weight loss is a comprehensive program that includes lifestyle interventions, such as dietary changes and increased physical activity, rather than relying on dietary supplements. If supplements are considered, vitamin/mineral supplementation or protein supplements may be indicated in specific cases, but only under the guidance of a healthcare professional 1.

From the Research

Weight Loss Supplements in Australia

• The most evidence-based peer-reviewed weight loss supplement in Australia is not explicitly stated in the provided studies.
• However, some studies mention the use of certain supplements for weight loss, such as:
  • Conjugated linoleic acid and green tea extract, which may have influenced weight loss in patients with social anxiety disorder 2.
  • Garcinia cambogia, which is commonly promoted for weight loss but has been associated with liver injury, especially when combined with green tea 3.
• It is essential to note that the effectiveness and safety of weight loss supplements can vary greatly, and more research is needed to determine their efficacy.
• The use of evidence-based research is crucial in evaluating the effectiveness of weight loss supplements, as it ensures that the research is worthwhile, valid, and accessible 4.
• Clinical guidelines should be based on a thorough evaluation of the evidence, and strong recommendations should be made with caution, especially when the certainty of the evidence is low or very low 5.