Magnesium Threonate and Egg Retrieval
Magnesium threonate can be safely continued during egg retrieval procedures, as there is no evidence of harm and current guidelines do not restrict magnesium supplementation in women undergoing assisted reproductive technology.
Evidence-Based Assessment
The available medical literature and clinical guidelines provide no specific contraindications or warnings regarding magnesium threonate use during egg retrieval procedures:
No guideline restrictions exist: The American College of Rheumatology guidelines for reproductive health during assisted reproductive technology (ART) procedures do not mention magnesium or magnesium threonate as substances requiring discontinuation 1.
Selective medication restrictions are clearly defined: When medications pose risks during ovarian stimulation and egg retrieval, guidelines explicitly identify them—such as aspirin being withheld before retrieval due to bleeding concerns, or cyclophosphamide being avoided due to direct follicular damage 1.
Supplement guidance focuses elsewhere: Current evidence-based recommendations for fertility supplementation emphasize folic acid, CoQ10, omega-3 fatty acids, and antioxidants, with no mention of concerns regarding magnesium compounds 2, 3, 4.
Clinical Context
The absence of magnesium threonate in fertility guidelines reflects its safety profile rather than oversight:
Magnesium is an essential mineral with well-established safety in reproductive-age women 4, 5.
Unlike anticoagulants that must be carefully timed around the retrieval procedure, or immunosuppressants that may affect oocyte quality, magnesium supplementation does not interfere with ovarian stimulation protocols 1.
The primary concerns during egg retrieval relate to thrombosis risk, ovarian hyperstimulation syndrome, and bleeding complications—none of which are associated with magnesium supplementation 1.
Practical Recommendations
Continue magnesium threonate through the egg retrieval process without interruption:
No dose adjustment or timing modifications are necessary around the retrieval procedure 2.
Focus clinical attention on evidence-based interventions that actually impact fertility outcomes, such as folic acid supplementation (800 mcg/day), lifestyle modifications including alcohol cessation, and appropriate management of any underlying medical conditions 2, 6.
Avoid delaying or modifying proven fertility treatments in favor of unsubstantiated supplement concerns 2.
Important Caveats
While magnesium threonate appears safe, recognize the broader context of supplement use in fertility treatment:
Most dietary supplements marketed for fertility lack robust evidence of efficacy, with 25% of products having no expected benefit and only 41.7% demonstrating higher expected efficacy 5.
The evidence for most nutritional supplements improving live birth rates remains very low quality, though they generally pose minimal risk of harm 4.
Women should prioritize evidence-based interventions over unproven supplements, particularly given that age remains the most significant factor in oocyte quality 2.