What is the treatment plan for a patient who has experienced sexual assault, including necessary laboratory tests and antibiotic prescriptions?

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From the Guidelines

A comprehensive treatment plan for a sexual assault patient should prioritize both medical and psychological care, including prophylactic antibiotic treatment, emergency contraception, and psychological support, as outlined in the most recent guidelines from the Centers for Disease Control and Prevention (CDC) 1.

Initial Management

Initial management involves obtaining a detailed history, performing a thorough physical examination, and collecting forensic evidence with the patient's consent. Essential laboratory tests include:

  • Pregnancy testing
  • HIV
  • Hepatitis B and C
  • STI screening (gonorrhea, chlamydia, syphilis, and trichomoniasis)

Prophylactic Antibiotic Treatment

Prophylactic antibiotic treatment typically includes:

  • Ceftriaxone 500 mg IM once for gonorrhea
  • Doxycycline 100 mg orally twice daily for 7 days for chlamydia
  • Metronidazole 2 g orally once for trichomoniasis

HIV Post-Exposure Prophylaxis

For HIV post-exposure prophylaxis, consider tenofovir/emtricitabine plus dolutegravir within 72 hours of exposure if risk is significant, as recommended by the CDC 1.

Emergency Contraception

Emergency contraception should be offered, such as levonorgestrel 1.5 mg orally once or ulipristal acetate 30 mg orally once, ideally within 72-120 hours of the assault.

Psychological Support

Psychological support is crucial, including crisis intervention, trauma-informed care, and referral to specialized counseling services. Follow-up care should be arranged for repeat testing, vaccination completion, and ongoing psychological support.

Follow-Up Care

Follow-up care should include a visit within 1 week of presentation to assess injury healing and to ensure that counseling has been arranged, as well as reassessment for STIs and pregnancy testing at 2 weeks, and repeat testing for syphilis and HIV at 6 weeks, 3 months, and 6 months after the assault if initial test results were negative and infection in the assailant could not be ruled out 1.

From the Research

Treatment Plan for Sexual Assault Victims

A treatment plan for a patient who has been sexually assaulted should prioritize their immediate medical needs, including treatment of injuries and prevention of unwanted pregnancy and sexually transmitted infections (STIs) 2. The plan should also address the patient's psychological and emotional well-being.

Laboratory Tests

The following laboratory tests should be ordered:

  • Human immunodeficiency virus (HIV) test
  • Sexually transmitted infection (STI) tests, including:
    • Chlamydia
    • Gonorrhea
    • Hepatitis B
  • Pregnancy test

Antibiotic Prophylaxis

Antibiotic prophylaxis should be considered to prevent STIs, including:

  • Ceftriaxone and azithromycin for gonorrhea and chlamydia 3, 4
  • Penicillin G formulations for syphilis 3
  • Local prevalence of infections and resistance to antibiotics should be considered when deciding on antibiotic prophylaxis 2

Additional Considerations

  • Emergency contraception should be offered to prevent unwanted pregnancy 2
  • Psychosocial support and risk assessment of vulnerabilities, including self-harm or domestic violence, should be addressed and acted on depending on identified needs 2
  • Follow-up care, including STI screening and HIV testing, should be scheduled 2 weeks after the initial visit, unless symptoms develop sooner 2

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Immediate medical care after sexual assault.

Best practice & research. Clinical obstetrics & gynaecology, 2013

Research

Sexually transmitted infections in pregnancy - An update on Chlamydia trachomatis and Neisseria gonorrhoeae.

European journal of obstetrics, gynecology, and reproductive biology, 2020

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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