From the Research
Glucocorticoids do not typically cause monocytosis, but rather can induce monocytopenia or have a complex effect on monocyte counts and function. When considering the effects of glucocorticoids on monocytes, it's essential to look at the most recent and highest quality studies. According to a study published in 2018 1, glucocorticoids can induce apoptosis in proinflammatory monocytes, which suggests a potential decrease in monocyte counts. Another study from 2019 2 highlights the complex action of glucocorticoids on monocytes and macrophages, including the induction of anti-inflammatory mediators and differentiation of anti-inflammatory phenotypes. Key points to consider include:
- The effects of glucocorticoids on monocytes can vary depending on the specific context and cell type
- Glucocorticoids can induce apoptosis in proinflammatory monocytes, potentially leading to a decrease in monocyte counts
- The impact of glucocorticoids on monocyte function and counts is complex and can involve multiple mechanisms, including the induction of anti-inflammatory mediators and changes in cell migration and adhesion
- Older studies, such as those from 1975 3 and 1976 4, may provide different insights into the effects of glucocorticoids on monocytes, but should be considered in the context of more recent research. Overall, the relationship between glucocorticoids and monocyte counts is more complex than a simple cause-and-effect, and healthcare providers should be aware of the potential for glucocorticoids to affect monocyte function and counts in various ways.