Chlor-Trimeton is the Brand Name for Chlorpheniramine
Chlor-Trimeton is the trade name under which chlorpheniramine maleate was introduced in the United States in July 1950 and remains available on the market today. 1, 2
Drug Identity and Classification
- Chlorpheniramine maleate is a first-generation H1 antihistamine of the alkylamine class that has been in clinical use for over 70 years 1, 3
- The brand name Chlor-Trimeton specifically refers to the chlorpheniramine maleate formulation marketed since 1950 2
- This medication is widely available as an over-the-counter product under various trade names, with Chlor-Trimeton being the original and most recognized brand 2
Clinical Applications
- Chlorpheniramine under the Chlor-Trimeton brand is indicated for temporary relief of hay fever and upper respiratory allergy symptoms including runny nose, sneezing, itchy nose or throat, and itchy, watery eyes 4
- The standard formulation contains 4 mg chlorpheniramine maleate per tablet 4
- Adult dosing is 1 tablet every 4 to 6 hours, not exceeding 6 tablets in 24 hours 4
Historical Significance
- Chlorpheniramine (Chlor-Trimeton) was discovered to have selective serotonin-reuptake inhibitor (SSRI) properties as early as 1969 by Nobel Laureate Professor Arvid Carlsson, though this property was never formally developed for psychiatric indications 2
- Had chlorpheniramine been tested for depression in the 1970s, it could have been available as a safe SSRI approximately 15 years before fluoxetine reached the market in 1987 2