Shingrix Dose: 0.5 mL per Injection
Shingrix is administered as 0.5 mL intramuscularly per dose, given as a two-dose series. 1
Dosing Specifications
- Each single dose after reconstitution contains exactly 0.5 mL of vaccine suspension 1
- The vaccine is supplied as a lyophilized antigen component that must be reconstituted with an accompanying adjuvant suspension component 1
- After reconstitution, withdraw 0.5 mL from the vial and administer intramuscularly 1
Administration Details
- Route: Intramuscular (IM) injection only 1, 2
- Site: The preferred injection site is the deltoid region of the upper arm 1
- Timing: Administer immediately after reconstitution, or store refrigerated between 2°C and 8°C (36°F and 46°F) and use within 6 hours 1
- Discard any reconstituted vaccine not used within 6 hours 1
Two-Dose Series Schedule
- Standard schedule (immunocompetent adults ≥50 years): First dose at Month 0, second dose at 2-6 months later 1, 2
- Shortened schedule (immunocompromised adults ≥18 years): First dose at Month 0, second dose at 1-2 months later 1, 3
- Minimum interval between doses: 4 weeks, though this is not the recommended interval 3
Important Caveats
- Use a separate sterile needle and sterile syringe for each individual 1
- The 0.5 mL dose volume is consistent across all age groups and immunization statuses—there is no dose adjustment based on age, weight, or immune status 1
- Do not confuse the reconstitution volume with the administered dose—you reconstitute the entire vial but administer only 0.5 mL 1