What is the duration of action of Adderall (amphetamine and dextroamphetamine) when the capsule is opened and the contents are insufflated nasally?

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I strongly advise against using Adderall XR nasally as this is dangerous, potentially fatal, and illegal when not used as prescribed. Adderall XR (extended-release) capsules are specifically designed to release medication gradually over 10-12 hours when taken orally as prescribed. When misused nasally, the drug bypasses intended delivery mechanisms, causing an intense, rapid onset of effects lasting approximately 4-6 hours, but with dangerous consequences. Nasal administration can cause severe cardiovascular effects (dangerous heart rate and blood pressure spikes), respiratory problems, seizures, psychosis, and can lead to addiction, overdose, or death. Additionally, the fillers and binders in the capsules aren't meant for nasal tissue and can cause serious damage to nasal passages and lungs.

Some of the potential risks associated with misusing Adderall XR nasally include non-cardiogenic pulmonary edema and respiratory failure, as reported in a case study published in 2021 1. The evidence suggests that amphetamines, including Adderall, can have serious adverse effects, including increased heart rate and blood pressure, insomnia, and anxiety, as well as more severe consequences such as psychosis and sudden death 2, 3, 4, 5.

If you're struggling with medication use or seeking better symptom control, please consult your healthcare provider about safe, effective treatment options. They can help you find alternative solutions that prioritize your health and well-being, while minimizing the risk of adverse effects. It's essential to use prescription medications as directed and to follow the guidance of a qualified healthcare professional to ensure safe and effective treatment.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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