What is the recommended dosage of Jovia (rosuvastatin) for an adult patient?

Jovia (Rosuvastatin) Dosage

For most adult patients, start rosuvastatin at 10 mg once daily, which reduces LDL-C by approximately 50%, though the full dosage range is 5-40 mg once daily depending on cardiovascular risk and treatment goals. 1

Standard Adult Dosing

• Dosage range: 5 mg to 40 mg orally once daily 1
• Administration: Take at any time of day, with or without food 1
• Monitoring: Assess LDL-C as early as 4 weeks after initiation and adjust dosage accordingly 1

Intensity-Based Dosing Strategy

The appropriate dose depends on your patient's cardiovascular risk profile and treatment indication:

High-Intensity Therapy (20-40 mg daily)

• Established ASCVD patients ≤75 years: Use rosuvastatin 20-40 mg daily for approximately 50-63% LDL-C reduction 2
• LDL-C ≥190 mg/dL: Initiate high-intensity therapy regardless of other risk factors 2
• Very high-risk patients: Those with multiple major risk factors, diabetes, severe uncontrolled risk factors, or metabolic syndrome targeting LDL <70 mg/dL 2

Moderate-Intensity Therapy (5-10 mg daily)

• Primary prevention (ages 40-75): Use rosuvastatin 5-10 mg daily for 30-49% LDL-C reduction 2, 3
• Patients >75 years with ASCVD: Moderate-intensity therapy is more appropriate as there is no clear evidence of additional benefit from high-intensity therapy in this age group 2

Critical Dosing Adjustments

Asian Patients

• Start at 5 mg once daily due to approximately 2-fold higher rosuvastatin plasma concentrations compared to Caucasian patients 3, 1
• This applies to Japanese, Chinese, Malay, and Asian Indian populations 3
• Common pitfall: Failing to adjust the starting dose for Asian ethnicity significantly increases myopathy risk due to higher drug exposure 3

Severe Renal Impairment (CrCl <30 mL/min/1.73 m²)

• Start at 5 mg once daily 1
• Maximum dose: 10 mg once daily 2, 1
• No adjustment needed for mild to moderate renal impairment 1

Drug Interaction Dose Caps

Critical interactions requiring dose limitations: 1

• Cyclosporine, tacrolimus, everolimus, sirolimus: Do not exceed 5 mg daily (7-fold increase in rosuvastatin exposure with severe rhabdomyolysis risk) 2, 1
• Teriflunomide, enasidenib, capmatinib: Do not exceed 10 mg daily 1
• Fostamatinib, febuxostat: Do not exceed 20 mg daily 1
• Gemfibrozil: Avoid concomitant use; if necessary, start at 5 mg and do not exceed 10 mg daily 1
• Certain antivirals (atazanavir/ritonavir, lopinavir/ritonavir): Start at 5 mg, do not exceed 10 mg daily 1
• Resmetirom (for MASH/NASH): Limit to 20 mg daily 2
• Darolutamide: Do not exceed 5 mg daily 1

Pediatric Dosing

Heterozygous Familial Hypercholesterolemia (HeFH)

• Ages 8 to <10 years: 5-10 mg once daily 1
• Ages ≥10 years: 5-20 mg once daily 1

Homozygous Familial Hypercholesterolemia (HoFH)

• Ages ≥7 years: 20 mg once daily 1

Key Clinical Considerations

• Comparative efficacy: Rosuvastatin demonstrates superior LDL-C lowering compared to atorvastatin, simvastatin, and pravastatin at equivalent doses 2
• Safety profile: Myopathy incidence <0.1% at recommended doses of 5-40 mg daily 2
• Antacid interaction: When taking with aluminum and magnesium hydroxide antacids, administer rosuvastatin at least 2 hours before the antacid 1
• Missed dose: Do not double up; resume with the next scheduled dose 1