What could be causing my stomach discomfort, empty feeling, and chills?

Stomach Discomfort with Empty Feeling and Chills: Clinical Approach

Your symptoms of stomach discomfort, empty feeling, and chills require immediate assessment for serious causes—particularly infection or inflammation—before considering functional disorders like dyspepsia or IBS.

Immediate Risk Stratification

The presence of chills alongside abdominal symptoms is a red flag that demands urgent evaluation for infectious or inflammatory processes:

• Fever with abdominal pain constitutes a challenging clinical situation that raises suspicion for intra-abdominal infection, abscess, or conditions requiring immediate surgical or medical attention 1
• Check your temperature immediately—documented fever (≥38°C/100.4°F) with abdominal pain warrants same-day medical evaluation 1
• CT abdomen and pelvis with IV contrast is the preferred initial imaging when fever accompanies nonlocalized abdominal pain, as it rapidly evaluates for abscesses, inflammatory conditions, and other acute pathology 1
• Weight loss, persistent vomiting, bloody stools, or inability to maintain adequate nutrition require urgent gastroenterology referral 2, 3

Differential Diagnosis Framework

If Fever/Chills Are Present (Infectious/Inflammatory)

• Acute gastroenteritis is the most common cause of abdominal pain with fever and chills, typically presenting with nausea, vomiting, diarrhea, and systemic symptoms 4
• Intra-abdominal abscess from conditions like appendicitis, diverticulitis, or inflammatory bowel disease can present with fever and diffuse abdominal pain 1
• Neutropenic enterocolitis or opportunistic infections should be considered if you have recent chemotherapy or immunosuppression 1

If No Fever (Functional/Motility Disorders)

• Functional dyspepsia, particularly postprandial distress syndrome, commonly causes upper abdominal discomfort, early satiety, bloating, and an "empty" sensation, though chills are atypical 1, 5
• The "empty feeling" may represent early satiation from impaired fundic accommodation or delayed gastric emptying 1
• Irritable bowel syndrome presents with abdominal discomfort associated with altered bowel habits, visceral hypersensitivity, and brain-gut axis dysregulation 1
• Chills without documented fever may represent stress-induced sympathetic activation or anxiety, which commonly coexist with functional GI disorders 1

Essential Diagnostic Workup

Laboratory Testing

• Obtain full blood count to assess for anemia, infection (elevated WBC), or inflammatory markers 6
• H. pylori stool antigen or breath testing is recommended for all patients with dyspeptic symptoms, as eradication resolves symptoms in a subset and may alter natural history 6, 5
• Serum lipase and liver function tests if upper abdominal pain predominates 6
• Celiac serology if overlapping IBS-type symptoms are present 6

Imaging Strategy

• If fever is documented: CT abdomen/pelvis with IV contrast is first-line imaging (rated 8/9 by ACR) 1, 6
• If no fever and symptoms are chronic: imaging is typically not required initially unless alarm features present 1, 5
• Plain radiography has limited diagnostic value and should not be relied upon 1, 6

Treatment Algorithm

Step 1: Empiric Therapy While Awaiting Results

• Initiate high-dose proton pump inhibitor (omeprazole 20-40 mg once daily before meals) for 4-8 weeks as first-line therapy for dyspeptic symptoms 6, 5, 2
• Avoid trigger foods and implement regular exercise without overly restrictive diets that risk malnutrition 6, 2
• Acetaminophen for symptomatic pain relief if needed (maximum 3000 mg/24 hours, avoid with alcohol use) 7

Step 2: H. pylori Eradication

• If H. pylori testing is positive, complete antibiotic eradication therapy and reassess symptoms, as this is the only intervention that may alter the natural history of functional dyspepsia 6, 5

Step 3: If PPI Fails After 4-8 Weeks

• Tricyclic antidepressants (e.g., amitriptyline 10-25 mg at bedtime, titrated up) work as neuromodulators to reduce abnormal nerve sensitivity in the gut-brain axis 6, 5
• Consider prokinetic agents (metoclopramide, prucalopride) if early satiety and postprandial fullness predominate 5

Step 4: Non-Pharmacologic Interventions

• Cognitive behavioral therapy and gut-directed hypnotherapy improve bloating symptoms and quality of life by addressing the dysregulated brain-gut axis 5
• Diaphragmatic breathing techniques provide immediate symptom relief by reducing vagal tone and sympathetic activity 5

Critical Pitfalls to Avoid

• Do not ignore chills—always measure temperature objectively, as subjective chills with documented fever require urgent evaluation for infection 1
• Do not delay empiric treatment while pursuing extensive diagnostic workup; symptomatic therapy can begin after excluding serious pathology 2
• Do not overlook psychosocial factors—chronic stress strongly predicts persistence of functional GI symptoms and requires addressing 1, 2
• In elderly patients, laboratory tests may be normal despite serious infection, making imaging even more critical 1