What is the proper procedure for administering an intramuscular (IM) injection, considering patient position and medical history?

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Proper Procedure for Administering Intramuscular (IM) Injections

Administer IM injections at a 90-degree angle perpendicular to the skin surface using the deltoid muscle in adults and the anterolateral thigh in infants, with needle length of 1-1½ inches (22-25 gauge) for adults and 7/8-1 inch for infants—never use the buttock due to sciatic nerve injury risk and decreased medication efficacy. 1, 2, 3

Site Selection by Age Group

Adults (>18 years)

  • Use the deltoid muscle as the preferred site for routine IM injections, including vaccines and vitamin B12 1, 2, 3
  • The anterolateral thigh is an acceptable alternative site if the deltoid is not suitable 1, 2
  • Administer the injection 4 fingerbreadths (approximately 9 cm) below the mid-acromion point to avoid underlying neurovascular structures, particularly the axillary nerve and posterior circumflex humeral artery 4
  • Never inject in the upper half of the deltoid muscle 4

Infants (<12 months)

  • Use the anterolateral aspect of the thigh as the preferred site, which provides the largest muscle mass in this age group 1, 2, 3
  • The deltoid muscle is not recommended due to inadequate muscle mass 1

Toddlers and Children (12 months to 18 years)

  • Use the deltoid muscle if adequate muscle mass is present; otherwise, use the anterolateral thigh 1, 2, 3
  • The anterolateral thigh remains the safer option for younger toddlers 3

Needle Specifications

Adults

  • Needle length: 1 to 1½ inches (25-38 mm) 1, 2, 3
  • Needle gauge: 22-25 gauge 1, 2, 3
  • The needle must be long enough to reach muscle mass and prevent seepage into subcutaneous tissue, but not so long as to involve underlying nerves, blood vessels, or bone 1, 2

Infants

  • Needle length: 7/8 to 1 inch 1, 2, 3
  • Needle gauge: 22-25 gauge 1, 2

Toddlers and Children

  • Needle length: 7/8 to 1¼ inches 1, 2, 3
  • Needle gauge: 22-25 gauge 1, 2

Injection Technique

Angle of Insertion

  • Insert the needle at a 90-degree angle perpendicular to the skin surface 1, 2, 3, 5
  • This 90-degree angle is critical because deviating from the recommended route can reduce medication efficacy or increase local adverse reactions 1
  • While one study suggests angles between 72-90 degrees may be acceptable, the standard guideline remains 90 degrees 6, 5

Volume Considerations

  • Maximum volume for deltoid injections: 1-2 mL in adults 1
  • For volumes >2 mL, use the anterolateral thigh or ventrogluteal site instead, as these sites have greater muscle mass 1
  • Routine deltoid vaccinations typically use volumes of 0.5-1 mL 1

Multiple Injections

  • When administering multiple IM injections in the same limb, separate injection sites by more than 1 inch (2.5 cm) to differentiate any local reactions 1
  • Document the location of each injection in the medical record 1

Aspiration

  • Aspiration before injection is not necessary, as no data support this as a required procedure according to the CDC 1

Critical Sites to Avoid

Never Use the Buttock

  • The buttock should never be used for routine IM injections due to:
    • Risk of sciatic nerve injury 1, 2, 3
    • Decreased medication immunogenicity and efficacy from inadvertent subcutaneous or deep fat tissue injection 1, 3
    • Reduced drug absorption compared to other sites 1

Other Sites to Avoid

  • Areas with lipohypertrophy, scars, or tissue abnormalities should be avoided 2
  • For insulin injections specifically, avoid a circle with a 2-inch radius around the navel 7

Common Pitfalls and How to Avoid Them

Inadequate Needle Length

  • Using a needle that is too short results in subcutaneous rather than intramuscular delivery, reducing medication efficacy 1
  • Always select needle length based on patient age, body size, and muscle mass 1, 2

Incorrect Site Selection

  • Injecting into the buttock carries both safety risks (sciatic nerve injury) and efficacy concerns (decreased drug absorption) 1
  • Always use the deltoid in adults or anterolateral thigh in infants unless contraindicated 1, 2, 3

Improper Angle

  • Deviating from the 90-degree angle can reduce medication efficacy or increase adverse reactions 1
  • Ensure the needle is inserted perpendicular to the skin surface 1, 2, 3

One-Size-Fits-All Approach

  • Failing to individualize needle selection based on age, muscle mass, and injection volume increases the risk of improper administration 1
  • Always assess the patient's muscle mass and select appropriate needle specifications 1, 2

References

Guideline

Intramuscular Injection Technique

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

Guideline

Injection Techniques and Needle Sizes for Various Age Groups and Injection Types

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Preferred Site for Intramuscular Vitamin B12 Injections

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Intramuscular injection angle: evidence for practice?

Nursing praxis in New Zealand inc, 2002

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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