What is the cause of fatigue in a male patient?

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Last updated: April 18, 2025 • View editorial policy

Differential Diagnosis for Low Energy Male

  • Single Most Likely Diagnosis + Depression: A common condition that can cause persistent feelings of low energy, sadness, and loss of interest in activities.
  • Other Likely Diagnoses + Anemia: A condition characterized by low red blood cell count or hemoglobin, leading to fatigue and low energy. + Hypothyroidism: A condition where the thyroid gland doesn't produce enough hormones, causing fatigue, weight gain, and low energy. + Sleep Apnea: A sleep disorder that can cause fatigue, low energy, and daytime sleepiness due to disrupted sleep patterns. + Chronic Fatigue Syndrome: A condition characterized by persistent and unexplained fatigue that is not relieved by rest.
  • Do Not Miss Diagnoses + Heart Failure: A condition where the heart is unable to pump enough blood, leading to fatigue, shortness of breath, and low energy. + Diabetes: A condition where the body is unable to regulate blood sugar levels, leading to fatigue, weight loss, and low energy. + Chronic Kidney Disease: A condition where the kidneys are damaged, leading to fatigue, weakness, and low energy. + Cancer: Certain types of cancer, such as leukemia or lymphoma, can cause fatigue, low energy, and weight loss.
  • Rare Diagnoses + Addison's Disease: A rare condition where the adrenal glands don't produce enough hormones, leading to fatigue, weight loss, and low energy. + Pernicious Anemia: A rare condition where the body is unable to absorb vitamin B12, leading to fatigue, weakness, and low energy. + Myasthenia Gravis: A rare condition where the immune system attacks the nerves, leading to muscle weakness, fatigue, and low energy.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.