From the Research
Agents Likely to Cause Headaches
- Various substances can cause headaches, including toxic agents like carbon monoxide (CO) and nitric oxide (NO) 1
- Medication overuse can lead to headache, with substances like caffeine, oestrogen, and opioids being common culprits 1
- Certain chemicals, such as those encountered in the workplace, can also trigger headaches 2
- Histamine has been known to cause vascular-type headaches for almost a hundred years 3
Agents Less Likely to Cause Headaches
- Lasmiditan, a 5-HT1F agonist, appears to be safe for patients with cardiovascular risk factors and may be less likely to cause headaches compared to other treatments 4
- Gepants, such as rimegepant or ubrogepant, have adverse effects like nausea and dry mouth, but may be less likely to cause headaches than other substances 4
- Antihistamines, particularly non-sedating H1 antihistamines, may have a role in preventing migraines and could potentially be less likely to cause headaches 3
Conclusion Not Applicable
No single agent can be definitively identified as the least likely to cause a headache, as the relationship between substances and headaches is complex and influenced by various factors, including individual susceptibility and the presence of underlying medical conditions 4, 1, 2, 5, 3