From the Research
The phosphoglycerate kinase reaction is the glycolytic reaction that produces ATP as a product, converting 1,3-bisphosphoglycerate to 3-phosphoglycerate while generating one ATP molecule, as supported by the most recent study 1.
Key Points
- The phosphoglycerate kinase reaction is one of the two ATP-producing reactions in the glycolytic pathway, as noted in 2 and further emphasized in 1.
- This reaction occurs in the latter half of glycolysis, known as the payoff phase, where the energy investment from earlier steps is recovered.
- The phosphoglycerate kinase reaction transfers a phosphate group from a high-energy intermediate directly to ADP, forming ATP through substrate-level phosphorylation, a process described in detail in 3.
- The study 4 highlights the importance of phosphoglycerate kinase in plant metabolism, demonstrating its role in adjusting metabolism and optimizing growth.
- The older studies 5 and 3 provide foundational knowledge on the kinetics and structure of phosphoglycerate kinase but are superseded by the more recent research 1 in terms of clinical relevance and understanding of the enzyme's role in glycolysis.
Reaction Details
- The reaction involves the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate.
- It generates one ATP molecule per converted molecule, contributing to the net gain of ATP in glycolysis.
- This process is crucial for energy production in cells, as outlined in the context of tumor metabolism in 1.