How to Give Nephrosteril
Nephrosteril (PHOSPHA 250™ NEUTRAL) should be administered orally with a full glass of water, taken with meals and at bedtime, at a dosage of 1-2 tablets four times daily for adults. 1
Standard Adult Dosing Protocol
- Adults should take 1-2 tablets four times daily (with breakfast, lunch, dinner, and at bedtime), always with a full glass of water and with food. 1
- The medication must be taken with meals to optimize absorption and minimize gastrointestinal side effects. 1
Pediatric Dosing Adjustments
- Children over 4 years of age should receive 1 tablet four times daily. 1
- Children under 4 years of age should only use this medication under direct physician supervision with individualized dosing. 1
Critical Administration Requirements
- Always administer with a full glass of water to ensure adequate dissolution and urinary excretion. 1
- Never skip the bedtime dose, as maintaining consistent urinary drug levels throughout the 24-hour period is essential for efficacy in urinary tract conditions. 1
- Take with food at each administration to reduce potential gastrointestinal irritation. 1
Renal Function Considerations
While the FDA label does not specify dose adjustments for renal impairment, caution is warranted in patients with significantly reduced kidney function (eGFR <30 mL/min), as phosphate-containing products require adequate renal clearance. Close monitoring of renal function and electrolytes may be necessary in this population, though specific guidance is not provided in the available evidence. 1
Common Pitfalls to Avoid
- Do not administer on an empty stomach, as this increases the risk of gastrointestinal upset and may reduce efficacy. 1
- Do not skip the bedtime dose, as overnight gaps in therapy can compromise urinary tract coverage. 1
- Ensure adequate hydration throughout the day beyond just the water taken with each dose to maintain optimal urinary flow and drug concentration. 1