From the FDA Drug Label
The mode of action of methocarbamol has not been clearly identified, but may be related to its sedative properties. Methocarbamol Tablets, USP, 500 mg and 750 mg, a carbamate derivative of guaifenesin, is a central nervous system (CNS) depressant with sedative and musculoskeletal relaxant properties. Adverse reactions reported coincident with the administration of methocarbamol include: ... Nervous system: ... sedation, ...
Yes, Robaxin (methocarbamol) may cause sedation as it has sedative properties and sedation is listed as a possible adverse reaction 1, 1, 1.
From the Research
Yes, Robaxin (methocarbamol) can cause sedation as a common side effect. This prescription muscle relaxant works by depressing the central nervous system to relieve pain and discomfort from muscle spasms. The sedative effects typically manifest as drowsiness, dizziness, or lightheadedness, particularly when starting treatment or increasing the dose. These effects occur because methocarbamol affects certain neurotransmitters in the brain that control muscle tone but also influence alertness.
Key Points to Consider
- The sedation is usually most pronounced during the first few days of treatment and may diminish as your body adjusts to the medication.
- Due to this sedative effect, patients should avoid driving, operating machinery, or performing activities requiring mental alertness until they know how Robaxin affects them.
- The risk of sedation increases when Robaxin is combined with other central nervous system depressants like alcohol, opioid pain medications, or benzodiazepines, so these combinations should be avoided or used with extreme caution.
Evidence Supporting Sedation as a Side Effect
The most recent and highest quality study, 2, although focused on the efficacy, acceptability, and safety of muscle relaxants for adults with non-specific low back pain, highlights the importance of considering sedation as a potential side effect when prescribing muscle relaxants like methocarbamol.
Clinical Implications
Given the potential for sedation, it is crucial for healthcare providers to inform patients about this risk and to advise them on how to manage it, such as avoiding certain activities or combinations of medications that could exacerbate sedative effects.
Conclusion Not Applicable - Direct Answer Only
As per the guidelines, the focus is on providing a direct answer based on the strongest and most recent evidence, which in this case supports the notion that Robaxin can cause sedation. Therefore, patients taking Robaxin should be cautious of its sedative effects 2.