From the FDA Drug Label
Pediatric: ...the recommended initial daily oral dose in infants is 2. 5 mL to 10 mL in divided doses. To treat constipation in newborns, the recommended initial daily oral dose of lactulose is 2.5 mL to 10 mL in divided doses.
- The dose may be adjusted to produce 2 or 3 soft stools daily.
- If the initial dose causes diarrhea, the dose should be reduced immediately.
- If diarrhea persists, lactulose should be discontinued 1
From the Research
Constipation in newborns should be treated with lactulose/lactitol-based medications for infants under 6 months, as they are authorized and effective, according to the most recent and highest quality study available 2. When treating constipation in newborns, it is essential to consider the most recent and effective treatment options.
- The treatment approach should prioritize the use of lactulose/lactitol-based medications for infants under 6 months, as recommended by the study published in Archives de pediatrie 2.
- For infants over 6 months, polyethylene-glycol can be used as an effective treatment option.
- In cases of fecal impaction, a high dose of PEG or repeated phosphate enemas may be necessary to disimpact the feces.
- Education on adapting toilets and promoting daily bowel movements is also crucial in restoring colic motility and preventing relapses.
- It is also important to evaluate and address any psychological concerns that may be contributing to the constipation. The use of prune juice, as studied in 3 and 4, may also be beneficial in softening stool consistency and improving stool frequency, but it is not the primary recommended treatment for newborns. It is essential to consult with a pediatrician before administering any medication or treatment to newborns, as their digestive systems are still developing, and improper treatment can lead to adverse consequences.