From the Research
Myo-Inositol 120g by Orthoplex White is a dietary supplement that can be beneficial for several health conditions, particularly polycystic ovary syndrome (PCOS), insulin resistance, and fertility issues, with a recommended dosage of 2-4 grams daily, as supported by the most recent and highest quality study 1.
Key Points to Consider
- The typical recommended dosage is 2-4 grams daily, usually divided into two doses (morning and evening), taken with meals.
- For PCOS specifically, a dose of 2 grams twice daily has shown effectiveness in research, as seen in a study comparing myo-inositol and metformin in women with PCOS undergoing IVF cycles 1.
- This supplement works by improving insulin sensitivity, which can help regulate menstrual cycles, reduce androgen levels, and potentially improve ovulation in women with PCOS.
- Myo-inositol may also help with mood regulation as inositol is involved in neurotransmitter signaling in the brain, with a study showing its favorable effects on parameters of mental health and plasma total antioxidant capacity levels 2.
Important Considerations
- When taking this supplement, consistency is key - results typically take 3-6 months to become noticeable.
- Myo-inositol is generally well-tolerated, though some people may experience mild gastrointestinal effects like nausea or diarrhea when first starting.
- If you're pregnant, breastfeeding, or taking medications, consult with a healthcare provider before beginning supplementation.
- For best absorption, take it with food and store the container in a cool, dry place.
Comparison with Other Treatments
- A study comparing myo-inositol and metformin in PCOS women undergoing ovulation induction cycles found that myo-inositol had a significantly higher live birth rate and improved menstrual cycles 3.
- Another study found that myo-inositol had beneficial effects on total testosterone, modified Ferriman-Gallwey scores, and serum high-sensitivity C-reactive protein levels compared to metformin in women with PCOS 4.
- A meta-analysis of randomized clinical trials found that myo-inositol and metformin had similar effects on fasting insulin, HOMA index, testosterone, and body mass index in women with PCOS, but myo-inositol had a lower risk of adverse events 5.