From the Research
Myo-inositol is the most effective type of inositol for PCOS, as it has been shown to improve insulin sensitivity, regulate ovulation, and reduce androgen levels. The recommended dosage is typically 2,000-4,000 mg (2-4 grams) daily, often divided into two doses, as supported by the latest evidence from 1. For optimal results, myo-inositol is frequently combined with D-chiro-inositol in a 40:1 ratio, which mimics the body's natural ratio. This combination is available in supplement form, with a common formulation being 2,000 mg of myo-inositol plus 50 mg of D-chiro-inositol daily.
Some key benefits of myo-inositol for PCOS include:
- Improving insulin sensitivity, which helps regulate ovulation and reduce androgen levels
- Reducing the risk of hyperstimulation syndrome in IVF treatments, as shown in 2
- Improving oocyte and embryo quality, fertilization rates, and clinical pregnancy rates, as demonstrated in 1
- Restoring spontaneous ovarian activity and fertility in most patients with PCOS, as reported in 3
When starting supplementation, it is recommended to begin with a lower dose and gradually increase to reduce potential mild side effects like nausea or digestive discomfort. Taking inositol with meals can improve absorption and minimize gastrointestinal issues. Consistency is important, as benefits typically appear after 3-6 months of regular use. Myo-inositol works by improving insulin sensitivity, which addresses the underlying insulin resistance that affects approximately 70% of women with PCOS and contributes to many of the syndrome's symptoms, as supported by the findings of 4.