From the Guidelines
Diapril is indicated for the treatment of hypertension, particularly in patients with diabetes or multiple cardiovascular risk factors, as evidenced by the ADVANCE trial, which showed a reduction in major macrovascular and microvascular events with the use of perindopril, an ACE inhibitor similar to Diapril 1. The primary use of Diapril, an ACE inhibitor, is in the management of hypertension, where it has been shown to reduce the risk of cardiovascular events. Key considerations in its use include:
- Starting dose: typically 5 mg once daily, with potential increase to 40 mg daily based on blood pressure response
- Mechanism of action: inhibition of angiotensin I to angiotensin II conversion, leading to reduced blood vessel constriction and decreased blood pressure
- Common side effects: dry cough, dizziness, headache, and fatigue
- Contraindications: pregnancy, especially during the second and third trimesters, due to the risk of fetal harm
- Monitoring requirements: regular blood pressure checks, kidney function tests, especially in patients with renal impairment or those taking diuretics The ADVANCE trial 1 demonstrated the benefits of intensive blood pressure control using an ACE inhibitor, perindopril, in patients with type 2 diabetes, highlighting the potential benefits of Diapril in similar patient populations. However, the decision to use Diapril should be individualized, considering the patient's overall clinical profile, including the presence of diabetes, cardiovascular risk factors, and potential for adverse effects.
From the FDA Drug Label
INDICATIONS AND USAGE Indapamide tablets are indicated for the treatment of hypertension, alone or in combination with other antihypertensive drugs. Indapamide tablets are also indicated for the treatment of salt and fluid retention associated with congestive heart failure The indications for Indapamide (also known as Diapril) are:
- Treatment of hypertension, alone or in combination with other antihypertensive drugs
- Treatment of salt and fluid retention associated with congestive heart failure 2
From the Research
Diapril Indications
- Diapril, also known as indapamide, is indicated for the treatment of hypertension and edema 3
- It is a new antihypertensive diuretic agent that shows an alteration in vascular reactivity to calcium and other agonists, suggesting the possibility of a direct vascular effect 3
- Indapamide is recommended in doses of 2.5 to 5 mg once a day for the treatment of mild to moderate hypertension 3, 4, 5
Therapeutic Uses
- Indapamide has diuretic properties and its site of action is in the cortical diluting segment of the distal tubules 3
- It is effective in lowering blood pressure in patients with mild to moderate hypertension, with a significant decrease in mean blood pressure and total peripheral resistance 3, 5
- Indapamide can be used as a first-line treatment for hypertension, either alone or in combination with other antihypertensive agents 4, 6, 5
Safety and Tolerability
- Indapamide is well-tolerated and has a low incidence of side effects, including hypokalemia and increased serum uric acid 5, 7
- It does not increase magnesium excretion, which distinguishes it from other diuretic formulations and may reduce the risk of sudden cardiac death 7
- Indapamide is safe to use in patients with impaired renal function, with little or no accumulation of the drug in the blood 3