Multi-Use Vial Spike Replacement
Yes, you can replace a spike on a multi-use vial with a new sterile spike, provided you maintain strict aseptic technique and the vial's sterility has not been compromised. 1
Key Requirements for Spike Replacement
When replacing a spike on a multi-use vial, you must adhere to the following infection control principles:
Sterile Technique Protocol
- Always use a completely sterile device (including both the new spike and any associated syringe) to access the multi-dose vial 1
- Cleanse the access diaphragm with 70% alcohol before inserting the new spike into the vial 1
- Avoid touching the access diaphragm during the spike replacement process to prevent contamination 1
Timing Considerations
- Replace the spike when 72 hours have elapsed since initial placement, as extrapolated from CDC administration set guidelines 2
- Replace immediately if any visible contamination or breach in sterility occurs 2
Critical Safety Measures
- Discard the entire multi-dose vial immediately if sterility is compromised at any point during spike replacement 1, 2
- Keep multi-dose vials away from the immediate patient treatment area to prevent inadvertent contamination by spray or spatter 1, 2
- Never reuse syringes even if the needle is changed when accessing multi-dose vials 1, 2
Common Pitfalls to Avoid
The most critical error is failing to maintain sterility during the spike replacement process. Any contact with non-sterile surfaces, failure to adequately cleanse the diaphragm, or touching the access point compromises the vial and necessitates its immediate disposal 1. Additionally, leaving a spike in place beyond 72 hours without replacement increases infection risk based on administration set guidelines 2.