PRP Injections Do Not Increase Penile Size
PRP injections into the penis are not recommended for penile enlargement, as there is no evidence supporting this indication and current use should be restricted to clinical trials only. 1
Current Evidence Status
The most recent European Association of Urology guidelines (2025) explicitly state that PRP for erectile dysfunction shows insufficient efficacy data and protocol variations limit evidence strength, restricting current use to clinical trials only. 1 This represents the highest quality guidance available and directly addresses intracavernous PRP therapy.
What PRP Has Been Studied For (Not Size Enhancement)
The available evidence examines PRP exclusively for:
- Erectile dysfunction treatment - with modest improvements in erectile function scores (mean IIEF-EF improvement of 3.21 points vs placebo), but no mention of size changes 1
- Peyronie's disease management - focused on curvature correction and plaque reduction, not penile enlargement 1, 2
Why Size Enhancement Is Not Supported
No clinical trials have evaluated PRP for penile size augmentation. 3, 4, 2 The systematic reviews examining PRP in urology (covering 18 studies with 373 patients total) focus entirely on erectile function restoration and Peyronie's disease, with outcome measures limited to:
- Intracavernous pressure measurements 3
- IIEF-5 erectile function scores 5, 6
- Penile duplex Doppler ultrasound for vascular assessment 3, 2
- Penile curvature angle measurements in Peyronie's disease 2
None of these studies measured or reported changes in penile length, girth, or overall size. 3, 2
Safety Considerations
While PRP appears relatively safe when used for studied indications, reported adverse effects include:
- Mild penile bruising and ecchymosis 5, 2
- Pain at injection site 5
- Transient hypotension (2 out of 90 patients) 2
- Hematomas 2
Clinical Recommendation
Do not offer PRP injections for penile enlargement. 1 The International Society of Thrombosis and Haemostasis consensus panel rated the clinical utility of PRP preparations in regenerative medicine as "uncertain" (median score 6/9), emphasizing that preparations are poorly standardized and many trials fail to define content and biological properties adequately. 1
What to Tell Patients
Patients seeking penile size enhancement should be counseled that:
- No FDA-approved treatments exist for penile enlargement in the absence of medical pathology 1
- PRP has only been studied for erectile dysfunction and Peyronie's disease, not size enhancement 3, 2
- Commercial availability does not equal proven efficacy 4
- Any use of PRP for size enhancement would be entirely experimental and should only occur within an ethical board-approved clinical trial 1
Common Pitfall to Avoid
Do not confuse PRP's theoretical regenerative properties with actual evidence for penile enlargement. 3 While PRP contains growth factors that promote angiogenesis and tissue regeneration in other contexts, this mechanism has never been demonstrated to increase penile size in clinical studies. 4, 2