From the Research
The maximum recommended dose of Motilium (domperidone) is 10 mg up to three times daily, with a maximum daily dose of 30 mg for adults, as higher doses may increase the risk of cardiac side effects, particularly QT prolongation, as noted in studies such as 1 and 2. This medication should be taken 15-30 minutes before meals and before bedtime if needed. For children, dosing is weight-based and should be determined by a healthcare provider. Treatment duration should generally not exceed one week. Motilium works by blocking dopamine receptors in the gut and chemoreceptor trigger zone, which increases gut motility and reduces nausea. Some key points to consider when prescribing domperidone include:
- The risk of cardiac side effects, particularly QT prolongation, which is why dosing is limited, as discussed in 1 and 2.
- Patients with liver impairment, cardiac conditions, or electrolyte abnormalities should use reduced doses or avoid the medication altogether, as noted in 3 and 4.
- Always follow your healthcare provider's specific instructions for your situation, and be aware of the potential for off-label use, as mentioned in 5. It's also important to note that domperidone carries a risk of cardiac side effects, particularly QT prolongation, which is why dosing is limited, and this risk increases with higher doses, in patients over 60 years old, those taking more than 30 mg daily, or when used with other QT-prolonging medications, as discussed in 1 and 2. Some of the key benefits and risks of domperidone are:
- Benefits: effective in reducing nausea and vomiting, improving gut motility, and relieving symptoms of gastroparesis, as noted in 1 and 4.
- Risks: cardiac side effects, particularly QT prolongation, as discussed in 1 and 2, and potential interactions with other medications. Overall, the use of domperidone should be carefully considered and monitored, taking into account the potential benefits and risks, as well as the individual patient's medical history and current health status, as discussed in 3, 4, and 5.