From the Guidelines
Humalog is the brand name for insulin lispro, a rapid-acting insulin analog used to control high blood sugar in adults and children with diabetes. According to the latest evidence, Humalog begins working faster than regular human insulin, typically starting to lower blood glucose within 15 minutes after injection, peaking in about 1 hour, and continuing to work for 2-4 hours 1. This rapid action makes it ideal for mealtime insulin coverage.
Key Characteristics of Humalog
- Rapid-acting insulin analog
- Begins working within 15 minutes after injection
- Peaks in about 1 hour
- Continues to work for 2-4 hours
- Ideal for mealtime insulin coverage
Forms and Administration
Humalog is available in various forms including vials, prefilled pens (Humalog KwikPen), cartridges, and as part of insulin pump therapy. Patients should always follow their healthcare provider's specific dosing instructions, as insulin requirements vary based on individual factors such as weight, diet, activity level, and overall health status. It's also important to note that while Humalog is a brand name, insulin lispro is also available as biosimilar products.
Clinical Considerations
The American Diabetes Association recommends individualized insulin regimens, taking into account factors such as carbohydrate intake, premeal glucose levels, and anticipated activity 1. Education on adjusting prandial insulin doses based on these factors can be effective and should be offered to most patients. Additionally, estimates of fat and protein content of meals can be incorporated into prandial dosing for added benefit.
From the FDA Drug Label
Insulin lispro-aabc is a rapid-acting human insulin analog used to lower blood glucose. HUMALOG was injected 0 to 2 minutes before the meal and postmeal LYUMJEV was injected 20 minutes after the start of the meal The brand name of insulin lispro is HUMALOG 2.
From the Research
Humalog Brand Name
- The brand name Humalog is associated with insulin lispro, a biosynthetic insulin analogue 3, 4.
- Insulin lispro is a quick-acting insulin analogue that has a more rapid onset of action and a shorter duration of action compared to soluble insulin preparations 3.
- The Humalog brand name is mentioned in the context of insulin lispro, which is used to treat diabetes mellitus 4, 5, 6.
- There is no mention of other brand names associated with insulin lispro in the provided studies.
Insulin Lispro Properties
- Insulin lispro has a reduced capacity for self-association in solution, which translates into more rapid absorption from subcutaneous sites 4.
- Insulin lispro has a more rapid onset and a shorter duration of glucose-lowering activity compared to human regular insulin 4.
- The pharmacological properties of insulin lispro provide the rationale for comparative clinical trials with human regular insulin in patients with type 1 or type 2 diabetes 4.
Clinical Trials and Studies
- Clinical trials have compared the efficacy and safety of insulin lispro with human regular insulin in patients with type 1 or type 2 diabetes 4, 5, 6.
- Studies have also compared the pharmacokinetic and pharmacodynamic profiles of insulin lispro with other rapid-acting insulin analogues, such as insulin aspart and glulisine 5, 6, 7.